How do you give amiodarone IV?
The current dosing recommendation for intravenous amiodarone is to give ≈1000 mg over the first 24 hours. The initial infusion should contain 3 mL of amiodarone injection (150 mg) in 100 mL D5W (concentration of 1.5 mg/mL). One should infuse this 100 mL over 10 minutes (15 mg/min) for a total of 150 mg.
Does amiodarone need special tubing?
Amiodarone adsorbs to polyvinyl chloride (PVC) tubing, but all of the clinical experience has been with PVC tubing and the concentrations and rates of infusion provided in DOSAGE AND ADMINISTRATION reflect dosing in these studies.
How is amiodarone supplied?
For rapid loading infusion: Add 150 mg (3 mL) of amiodarone 50 mg/mL injection to 100 mL 5% Dextrose Injection (final concentration = 1.5 mg/mL). For slow loading infusion: Add 900 mg (18 mL) of amiodarone 50 mg/mL injection to 500 mL 5% Dextrose Injection (final concentration = 1.8 mg/mL).
Can amiodarone be given in normal saline?
Amiodarone is incompatible with saline and should be administered solely in 5% dextrose solution.
Can amiodarone be given IV push?
Pulseless ventricular fibrillation/tachycardia: Administer via IV push. When administering amiodarone peripherally via IV push, follow the injection with a 10 to 20 mL bolus of IV fluid. Elevate the extremity for 10 to 20 seconds following to facilitate drug delivery to the central circulation.
How does IV amiodarone work?
Amiodarone injection belongs to the group of medicines known as antiarrhythmics. It works directly on the heart tissue and will slow the nerve impulses in the heart. This helps keep the heart rhythm normal. This medicine is to be given only by or under the supervision of your doctor.
Does amiodarone IV need filter?
Amiodarone is delivered from the pharmacy in a glass intravenous bottle and is administered by using an in-line filter. The filter is required because amiodarone quickly precipitates when mixed with intravenous fluid,9 a characteristic that can be a factor in the development of phlebitis.
Can you run amiodarone through peripheral IV?
Intravenous administration IV amiodarone must be administered via a central line. The only exception is the treatment of cardiac arrest; in this situation amiodarone may be administerd peripherally with extreme care to avoid extravasation.
Is amiodarone IV pushed?
Adult Dosage for Amiodarone: When using amiodarone to treat ventricular fibrillation or pulseless ventricular tachycardia, the first dose should be 300 mg IV/IO push. The second dose is delivered at 150mg IV/IO push.
When should I start IV after amiodarone?
Pa- tients who have been receiving IV therapy for more than 2 to 3 weeks can be started safely on mainte- nance doses of oral amiodarone (300- 400 mg/d).
What is IV amiodarone used for?
Amiodarone injection is used to treat life-threatening heart rhythm problems called ventricular arrhythmias. It is used in patients who have already been treated with other medicines that did not work well.
How fast do you push amiodarone?
Dosing protocols administering the bolus dose in smaller aliquots of 1 to 2 mg/kg/dose IV over 5 to 10 minutes have been recommended in order to reduce patient exposure to plasticizers, such as DEHP, which may be leached out of IV tubing, including polyvinyl chloride (PVC) tubing, by certain formulations of amiodarone.
What type of bag is used for amiodarone infusion?
Continuous infusions should be prepared in non-PVC bags to prevent adsorption of amiodarone to bag. Use of a 0.2 or 0.22 micron filter is recommended for intermittent and continuous infusions.
Do you need a filter for Amiodarone IV?
Continuous infusions should be prepared in non-PVC bags to prevent adsorption of amiodarone into bag. Use of a 0.2 or 0.22 micron filter is recommended for intermittent and continuous infusions. First dose: Give 300 mg (6 mL) IV direct UNDILUTED. A filter is not required for IV direct administration.
Can admixtures with amiodarone hydrochloride be stored at room temperature?
Admixtures containing amiodarone hydrochloride 600 micrograms/mL and either 5% dextrose injection or 0.9% sodium chloride injection were stored at room temperature … The loss of amiodarone from i.v. admixtures to flexible polyvinyl chloride (PVC) infusion bags and i.v. administration sets was studied.
How do I prepare amiodarone for continuous infusion?
Continuous infusions should be prepared in non-PVC bags to prevent adsorption of amiodarone into bag. Use of a 0.2 or 0.22 micron filter is recommended for intermittent and continuous infusions.