What is Leser-Trélat sign?
The sign of Leser-Trélat may be more precisely defined as the abrupt appearance of multiple seborrheic keratoses caused by an associated cancer and the rapid increase in their size and number. This definition is parallel to that of malignant acanthosis nigricans; both conditions are obligate paraneoplastic syndromes.
What is eruptive seborrheic keratosis?
Eruptive seborrheic keratoses (ESK) is a rare dermatological disorder characterized by the rapid appearance of several benign pigmented skin lesions. ESK presents as well-demarcated round or oval lesions with a verrucous surface.
Can seborrheic keratosis appear suddenly?
Signs & Symptoms Symptoms of Seborrheic Keratosis are limited to discolored skin lesions that appear to be “stuck on” the skin surface. These patches may appear suddenly, may vary in size, and tend to grow slowly. They may be round or oval-shaped, and vary in color from tan, yellowish-brown to black.
What causes sudden seborrheic keratosis?
It’s not clear what exactly causes seborrheic keratoses. They tend to run in families, so genes may be a cause. Normal skin aging plays a role because the growths are more common with age. Too much sun exposure may also play a role.
What does keratosis look like?
Seborrheic keratoses are roundish or oval-shaped patches on the skin with a “stuck on” appearance. They are sometimes described as waxy or scaly. They are raised above the skin and even when they are flat you can feel them with your finger.
What causes seborrheic keratosis to flare up?
There is no known cause of seborrheic keratoses. However, some research has found common factors among those who experience them. The growths appear to run in families. Exposure to the sun also seems to play a role in developing seborrheic keratoses.
What is the pathophysiology of Leser-Trélat sign?
This sign has been regarded as a rare but reliable cutaneous marker of internal malignancy. The pathogenesis of Leser-Trélat sign is still unknown. Leser-Trélat sign is not widely accepted as a paraneoplastic syndrome because seborrheic keratoses and cancer are common findings in the elderly.
What are the symptoms of Leser-Trélat?
The sudden development of seborrhoeic keratoses that increase in size and number over a short period of time. Accompanying signs and symptoms of malignant acanthosis nigricans (occurs in as many as 35% of cases) Pruritus (itching) may be the only symptom of the sign of Leser-Trélat and occurs in almost one half of patients.
What is Leser–Trélat sign due to colon cancer?
Many seborrheic keratoses on the back of a person with Leser–Trélat sign due to colon cancer The Leser–Trélat sign is the explosive onset of multiple seborrheic keratoses (many pigmented skin lesions), often with an inflammatory base. This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome.
Is Leser-Trélat sign a reliable cutaneous marker?
Leser-Trélat sign, or eruptive seborrheic keratosis, is defined as the association of the abrupt appearance of multiple seborrheic keratoses, often pruritic, with an underlying internal malignancy [1]. This sign has been regarded as a rare but reliable cutaneous marker of internal malignancy.