What is the pathogenesis of poliomyelitis?
During intestinal replication, the virus invades local lymphoid tissue and may enter the bloodstream, and then infect cells of the central nervous system. Poliovirus-induced destruction of motor neurons of the anterior horn of the spinal cord and brain stem cells results in distinctive paralysis.
How does poliovirus cause cell death?
We suggest that the poliovirus 2A protease induces apoptosis either by arresting cap-dependent translation of some cellular mRNAs that encode proteins required for cell viability, by preferential cap-independent translation of cellular mRNAs encoding apoptosis inducing proteins, or by cleaving other, yet unidentified …
What is the difference between polio and poliomyelitis?
Polio (also known as poliomyelitis) is a highly contagious disease caused by a virus that attacks the nervous system.
What are the stages of polio?
The course of the disease is divided into four stages:
- Prodromal Stage or Pre-Paralytic Stage- few hours to a few days and 1 to 3 days is the usual duration.
- Acute Stage-3 to 6 weeks from the onset of Poliomyelitis.
- Convalescent Stage- Duration 3 months.
- Stage of Recovery-This stage extends for almost 2 years.
What poliomyelitis means?
poliomyelitis. [ pō′lē-ō-mī′ə-lī′tĭs ] A highly communicable infectious disease caused by the poliovirus of the genus Enterovirus that causes inflammation of motor neurons of the spinal cord and brainstem, leading to paralysis, muscular atrophy, and often disability and deformity.
What is the scientific name for poliovirus?
A poliovirus, the causative agent of polio (also known as poliomyelitis), is a serotype of the species Enterovirus C, in the family of Picornaviridae. There are three poliovirus serotypes: types 1, 2, and 3. Poliovirus is composed of an RNA genome and a protein capsid.
Can polio infect mice?
Experimentally, poliomyelitis can be transmitted to monkeys and, in some cases, to mice by inoculation of PV directly into the CNS.
What are the 3 types of poliomyelitis?
There are three wild types of poliovirus (WPV) – type 1, type 2, and type 3. People need to be protected against all three types of the virus in order to prevent polio disease and the polio vaccination is the best protection.
What type of virus is poliovirus?
Poliovirus, a nonenveloped, positive-sense, single-stranded RNA virus, is a member of the Enterovirus genus within the family Picornaviridae.
Is poliovirus RNA or DNA?
Poliovirus, the prototypical picornavirus and causative agent of poliomyelitis, is a nonenveloped virus with a single-stranded RNA genome of positive polarity. The virion consists of an icosahedral protein shell, composed of four capsid proteins (VP1, VP2, VP3, and VP4), which encapsidates the RNA genome (1).